UK 383367

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UK-383367 是一种前胶原 C 蛋白酶抑制剂，IC50 为 44 nM，比 MMP 具有优异的选择性。

UK-383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. The purpose of our study was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expression is regulated by TGF-β2, BMP1 is biologically active, and BMP1 regulates LOX activity.

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UK-383367, UK 383367, UK383367

MAPK/ERK Signaling

p38 MAPK

Procollagen C proteinase

Others-Field

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348622-88-8

324.38

C15H24N4O4

>98% (HPLC)

In Vitro:?DMSO : 65 mg/mL (200.38 mM)

NC(=O)C1=NOC(=N1)[C@H](CCCC1CCCCC1)CC(=O)NO

(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years